Live Cell Imaging zeigt, wie Tau den axonalen Transport ausbremst

Abstract Tau is a cytoskeletal protein that regulates microtubule polymerization in the axon. In diseases such as Alzheimer’s disease, tau forms insoluble aggregates somatodendritic compartment. How assembly without disrupting axonal transport and how dysfunction contributes to disease remains unclear. Here, we show live cell imaging super-resolution microscopy can help solve key questions about physiological pathological role of tau.